Daniel C. Williams
B.S. Gonzaga University
Ph.D. University of Utah
Office - KESH 233
Personal Web Page
Courses: Biological Science I (BIOL 121), Fundamentals of Genetics (BIOL 350)
What happens as neurons degenerate? My research focuses on identification and characterization of the molecular pathways and cellular events involved in neurodegeneration. By triggering neruodegeneration in the genetic model organism Caenorhabditis elegans, we hope to isolate mutants that have altered neurodegeneraiton and identify the mutated gene at a molecular level. This will be coupled with microscopic analysis to characterize the cellular events that occur during neurodegeneration in real time.
Williams DC, Novick PJ. 2009. Analysis of SEC9 suppression reveals a relationship of SNARE function to cell physiology. PLoS One 4: e5549.
Boulin T, Gielen M, Richmond JE, Williams DC, Paoletti P, Bessereau JL. 2008. Eight genes are required for functional reconstruction of the C. elegans levamisole-sensitive acetylcholine receptor. Proc Natl Acad Sci USA 105: 18590-5.
Williams DC, Boulin T, Ruaud AF, Jorgensen EM, Bessereau JL. 2005. Characterization of Mos1-mediated mutagenesis in C. elegans: A method for the rapid identification of mutated genes. Genetics 169: 1779-85.
Bessereau JL, Wright A*, Williams DC, Schuske K, Davis MW, Jorgensen EM. 2001. Mobilization of a Drosophila transposon in the C. elegans germ line. Nature 413: 70-4.